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Gadolinium-enhanced neuroimaging has illuminated that BBB dysfunction is a foundational event in MS pathogenesis, occurring early in the disease process [261]

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Antioxidant treatments tend to decrease the epidermal inflammation by inactivating the free radicals and stabilize the membrane and prevent new epidermal destruction.[] PEMPHIGUS VULGARIS In pemphigus vulgaris, increased production of ROS from activated neutrophils has been found to decrease the concentrations of antioxidants in plasma and RBCs, resulting in oxidative stress

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